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Article

Advanced forms of MPNs are accompanied by chromosomal abnormalities that lead to dysregulation of TP53.

Blood advances - 26 Dec 2018

Marcellino Bridget K, Hoffman Ronald, Tripodi Joseph, Lu Min, Kosiorek Heidi, Mascarenhas John, Rampal Raajit K, Dueck Amylou, Najfeld Vesna

Abstract excerpt

The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and the prefibrotic form of primary myelofibrosis (PMF), frequently progress to more overt forms of MF and a type of acute leukemia termed MPN-accelerated phase/blast phase (MPN-AP/BP). Recent evidence indicates that dysregulation of the tumor suppressor tumor protein p53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30563882
DOI: 10.1182/bloodadvances.2018024018
PMCID: PMC6306879

Genes

TP53
MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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