Article
Chromosome 1 abnormalities in myeloid malignancies: a literature survey and karyotype-phenotype associations.
European journal of haematology - 1 Mar 2010
Caramazza Domenica, Hussein Kebede, Siragusa Sergio, Pardanani Animesh, Knudson Ryan A, Ketterling Rhett P, Tefferi Ayalew
Abstract excerpt
Chromosome 1 is the largest human chromosome and contains over 1600 known genes and 1000 novel coding sequences or transcripts. It is, therefore, not surprising that recurrent chromosome 1 abnormalities are regularly encountered in both neoplastic and non-neoplastic medical conditions. The current review is focused on myeloid malignancies where we summarize the relevant published literature and discuss specific...
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