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Article

TP53 Mutations in Myeloproliferative Neoplasms: Context-Dependent Evaluation of Prognostic Relevance.

American journal of hematology - 1 Apr 2025

Tefferi Ayalew, Abdelmagid Maymona, Loscocco Giuseppe G, Fathima Saubia, Begna Kebede H, Al-Kali Aref, Foran James, Palmer Jeanne, Badar Talha, Patnaik Mrinal M, Reichard Kaaren K, He Rong, Zepeda Mendoza Cinthya J, Shah Mithun, Orazi Attilio, Arber Daniel A, Pardanani Animesh, Vannucchi Alessandro M, Hiwase Devendra, Gangat Naseema, Guglielmelli Paola

Abstract excerpt

The clinical relevance of TP53 mutations (TP53 MUT ) in myeloproliferative neoplasms (MPN) and their prognostic interaction with MPN subtype designation has not been systematically studied. In the current study, 114 patients with MPN harboring TP53 MUT (VAF ≥ 2%) were evaluated for overall survival (OS), calculated from the time of TP53 MUT detection: chronic phase myelofibrosis (MF-CP; N = 61); blast-phase...

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Identifiers

PMID: 39873146
DOI: 10.1002/ajh.27609
PMCID: PMC11886478

Genes

TP53
CP
ASXL1
SRSF2
U2AF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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