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Article

The 423Q polymorphism of the X-linked inhibitor of apoptosis gene influences monocyte function and is associated with periodic fever.

Arthritis and rheumatism - 1 Nov 2009

Ferretti Massimo, Gattorno Marco, Chiocchetti Annalisa, Mesturini Riccardo, Orilieri Elisabetta, Bensi Thea, Sormani Maria Pia, Cappellano Giuseppe, Cerutti Elisa, Nicola Stefania, Biava Alessandra, Bardelli Claudio, Federici Silvia, Ceccherini Isabella, Baldi Maurizia, Santoro Claudio, Dianzani Irma, Martini Alberto, Dianzani Umberto

Abstract excerpt

OBJECTIVE: Hereditary periodic fever syndromes (HPFs) develop as a result of uncontrolled activation of the inflammatory response, with a substantial contribution from interleukin-1beta or tumor necrosis factor alpha (TNFalpha). The HPFs include familial Mediterranean fever (FMF), hyperimmunoglobulinemia D with periodic fever syndrome (HIDS), TNF receptor-associated syndrome (TRAPS), and cryopyrinopathies, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19877056
DOI: 10.1002/art.24905

Genes

XIAP
MEFV
MVK
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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