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DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16 945 semen samples

9 Jun 2020

Abstract excerpt

STUDY QUESTION: What is the relationship between sperm DNA fragmentation and oxidative stress (OS) with increasing male age? SUMMARY ANSWER: Sperm DNA fragmentation increases with age and is likely related to both defective spermatogenesis and increasing OS levels. WHAT IS KNOWN ALREADY: Sperm quality declines with age. The presence of DNA damage in a high fraction of spermatozoa from a raw semen sample is...

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PMID: 32976601
DOI: 10.1093/humrep/deaa159

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