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Article

Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics

14 Dec 2018

Abstract excerpt

ABSTRACT Bioenergetic failure, oxidative stress, and changes in mitochondrial morphology are common pathologic hallmarks of amyotrophic lateral sclerosis (ALS) in several cellular and animal models. Disturbed mitochondrial physiology has serious consequences for proper functioning of the cell, leading to the chronic mitochondrial stress. Mitochondria, being in the center of cellular metabolism, play a pivotal...

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PMID: 30550341
DOI: 10.1096/fj.201801843r

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