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Article

Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF-κB activity.

Journal of leukocyte biology - 1 Mar 2019

Puyo Carlos A, Earhart Alexander, Staten Nicholas, Prince Oliver A, Haug Colleen, Kollef Marin, Awad Michael

Abstract excerpt

Tracheitis secondary to placement of an endotracheal tube (ETT) is characterized by neutrophil accumulation in the tracheal lumen, which is generally associated with epithelial damage. Mitochondrial DNA (mtDNA), has been implicated in systemic inflammation and organ dysfunction following trauma; however, less is known about the effects of a foreign body on local trauma and tissue damage. We hypothesized that...

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Identifiers

PMID: 30548974
DOI: 10.1002/JLB.5A0718-254RR
PMCID: PMC7379990

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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