Mitochondrial DNA-Mediated Immune Activation After Resuscitation from Cardiac Arrest

Abstract excerpt

<h4>Background</h4> Post-cardiac arrest syndrome (PCAS) is characterized by a robust inflammatory response that contributes to significant morbidity and mortality among patients resuscitated from sudden cardiac arrest (SCA). Mitochondrial DNA (mtDNA), with its bacterial-like genomic motifs, has been implicated as a damage-associated molecular pattern in other inflammatory contexts, but its role as a pro-inflammato...

Topics

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• Cardiac Valve Diseases and Treatments
• COVID-19 Clinical Research Studies
• Cytosol
• DNA, Mitochondrial
• Infective Endocarditis Diagnosis and Management
• Mitochondria
• Mutation
• Neurodegenerative Diseases

Identifiers and source

Literature Corpus work

a2342bcf-613d-5726-a7a1-6e2d7f876c2c

DOI

10.1101/2025.02.14.25322318