Article
Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection.
Science translational medicine - 8 May 2013
Chen Swaine L, Wu Meng, Henderson Jeffrey P, Hooton Thomas M, Hibbing Michael E, Hultgren Scott J, Gordon Jeffrey I
Abstract excerpt
Urinary tract infections (UTIs) are common in women, and recurrence is a major clinical problem. Most UTIs are caused by uropathogenic Escherichia coli (UPEC). UPEC are generally thought to migrate from the gut to the bladder to cause UTI. UPEC form specialized intracellular bacterial communities in the bladder urothelium as part of a pathogenic mechanism to establish a foothold during acute stages of infection....
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