One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Abstract excerpt

Urinary tract infections (UTIs) are common (with 11 million cases annually in the USA), costly (with $5 billion spent per year), and increasingly antibiotic resistant (1). The clinical manifestations and symptomatologies of UTIs are strikingly complex and result from the interactions between diverse uropathogens and host urothelial tissues. The most common cause of UTIs is UPEC, which cause up to 80% of...

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