Article
Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections.
Science translational medicine - 22 Mar 2017
Schreiber Henry L, Conover Matt S, Chou Wen-Chi, Hibbing Michael E, Manson Abigail L, Dodson Karen W, Hannan Thomas J, Roberts Pacita L, Stapleton Ann E, Hooton Thomas M, Livny Jonathan, Earl Ashlee M, Hultgren Scott J
Abstract excerpt
Urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC) strains. In contrast to many enteric E. coli pathogroups, no genetic signature has been identified for UPEC strains. We conducted a high-resolution comparative genomic study using E. coli isolates collected from the urine of women suffering from frequent recurrent UTIs. These isolates were genetically diverse and varied in their...
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