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Enrichment of the fetal fraction in non-invasive prenatal screening reduces maternal background interference

29 Nov 2018

Abstract excerpt

Measurement of cell-free fetal DNA (cffDNA) is an indispensable process for non-invasive prenatal screening (NIPS). According to recent studies, cffDNA in maternal plasma can be enriched for various lengths of fragments, and a sufficient amount of cffDNA can effectively eliminate background interference on the part of maternal DNA. Therefore, we developed a simple and effective separation method, improved NIPS...

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PMID: 30518878
DOI: 10.1038/s41598-018-35738-0

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