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Article

The importance of determining the limit of detection of non‐invasive prenatal testing methods

27 Jan 2016

Abstract excerpt

OBJECTIVE: Several non-invasive prenatal testing (NIPT) methods, which analyze circulating fetal cell-free DNA (cfDNA) in maternal plasma, suggest a fetal fraction (FF) ≥ 4% for a reportable result, with the assumption that fetal aneuploidies may not be detectable at lower FF. This study determined the actual limit of detection (LOD) of a massively parallel sequencing-based NIPT method and evaluated its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26815144
DOI: 10.1002/pd.4780

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