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Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate

3 Dec 2018

Abstract excerpt

Human cytomegalovirus (HCMV) enters host by glycoprotein B (gB)-mediated membrane fusion upon receptor-binding to gH/gL-related complexes, causing devastating diseases such as birth defects. Although an X-ray crystal structure of the recombinant gB ectodomain at postfusion conformation is available, the structures of prefusion gB and its complex with gH/gL on the viral envelope remain elusive. Here, we...

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PMID: 30507948
DOI: 10.1371/journal.ppat.1007452

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