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Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling

1 Mar 2017

Abstract excerpt

During development, progenitor expansion, lineage allocation, and implementation of differentiation programs need to be tightly coordinated so that different cell types are generated in the correct numbers for appropriate tissue size and function. Pancreatic dysfunction results in some of the most debilitating and fatal diseases, including pancreatic cancer and diabetes. Several transcription factors regulating...

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PMID: 28248965
DOI: 10.1371/journal.pbio.2000949

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