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Celiac Disease: Role of the Epithelial Barrier

14 Jan 2017

Abstract excerpt

In celiac disease (CD) a T-cell-mediated response to gluten is mounted in genetically predisposed individuals, resulting in a malabsorptive enteropathy histologically highlighted by villous atrophy and crypt hyperplasia. Recent data point to the epithelial layer as an under-rated hot spot in celiac pathophysiology to date. This overview summarizes current functional and genetic evidence on the role of the...

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PMID: 28275682
DOI: 10.1016/j.jcmgh.2016.12.006

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