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Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages

29 Nov 2018

Abstract excerpt

Apolipoprotein E (ApoE) belongs to a class of cellular proteins involved in lipid metabolism. ApoE is a polymorphic protein produced primarily in macrophages and astrocytes. Different isoforms of ApoE have been associated with susceptibility to various diseases including Alzheimer's and cardiovascular diseases. ApoE expression has also been found to affect susceptibility to several viral diseases, including...

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PMID: 30496280
DOI: 10.1371/journal.ppat.1007372

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