Article
Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways.
Oncotarget - 6 Oct 2015
Wu Xinyan, Zahari Muhammad Saddiq, Ma Binyun, Liu Ren, Renuse Santosh, Sahasrabuddhe Nandini A, Chen Lily, Chaerkady Raghothama, Kim Min-Sik, Zhong Jun, Jelinek Christine, Barbhuiya Mustafa A, Leal-Rojas Pamela, Yang Yi, Kashyap Manoj Kumar, Marimuthu Arivusudar, Ling Min, Fackler Mary Jo, Merino Vanessa, Zhang Zhen, Zahnow Cynthia A, Gabrielson Edward, Stearns Vered, Roa Juan Carlos, Sukumar Saraswati, Gill Parkash S, Pandey Akhilesh
Abstract excerpt
Breast cancer is the most prevalent cancer in women worldwide. About 15-20% of all breast cancers are triple negative breast cancer (TNBC) and are often highly aggressive when compared to other subtypes of breast cancers. To better characterize the biology that underlies the TNBC phenotype, we profiled the phosphotyrosine proteome of a panel of twenty-six TNBC cell lines using quantitative high resolution Fourier...
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