Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties

20 Nov 2018

Abstract excerpt

Spermatogonial stem cells (SSCs) are unipotent germ cells that are at the foundation of spermatogenesis and male fertility. However, the underlying molecular mechanisms governing SSC stemness and growth properties remain elusive. We have recently identified chromodomain helicase/ATPase DNA binding protein 1-like (Chd1l) as a novel regulator for SSC survival and self-renewal, but how these functions are controlled...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Sperm and Testicular Function

Source

Identifiers

PMID: 30455250
DOI: 10.1128/mcb.00357-18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell PropertiesPMID 30455250Read ↗

Integration of Microarray and Single-Cell RNA-Seq Data and Machine Learning Allows the Identification of Key Histone Modification Gene Changes in Spermatogonial Stem CellsSemantic proximity Read ↗

PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1Semantic proximity Read ↗

USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/β-catenin signaling pathwaySemantic proximity Read ↗

miRNA Signature in Mouse Spermatogonial Stem Cells Revealed by High-Throughput SequencingSemantic proximity Read ↗

MicroRNA-322 Regulates Self-renewal of Mouse Spermatogonial Stem Cells through Rassf8Semantic proximity Read ↗

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteinsSemantic proximity Read ↗

Signaling molecules and pathways regulating the fate of spermatogonial stem cellsSemantic proximity Read ↗

Hsa-miR-1908-3p Mediates the Self-Renewal and Apoptosis of Human Spermatogonial Stem Cells via Targeting KLF2Semantic proximity Read ↗

Dissecting the spermatogonial stem cell niche using spatial transcriptomicsSemantic proximity Read ↗

Establishment of a proteome profile and identification of molecular markers for mouse spermatogonial stem cellsSemantic proximity Read ↗

Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humansSemantic proximity Read ↗

Sertoli cell‐derived exosomal MicroRNA‐486‐5p regulates differentiation of spermatogonial stem cell through PTEN in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.