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Rare, Pathogenic Germline Variants in Fanconi Anemia Genes Increase Risk for Squamous Lung Cancer

13 Nov 2018

Abstract excerpt

Abstract Purpose: Lung cancer is the leading cause of cancer deaths worldwide, with substantially better prognosis in early-stage as opposed to late-stage disease. Identifying genetic factors for lung squamous cell carcinoma (SqCC) risk will enable their use in risk stratification, and personalized intensive surveillance, early detection, and prevention strategies for high-risk individuals. Experimental Design:...

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PMID: 30425093
DOI: 10.1158/1078-0432.ccr-18-2660

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