Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reclassification of BRCA1 and BRCA2 variants of uncertain significance: a multifactorial analysis of multicentre prospective cohort

10 Nov 2018

Abstract excerpt

Background BRCA1 and BRCA2 (BRCA1/2) variants classified ambiguously as variants of uncertain significance (VUS) are a major challenge for clinical genetic testing in breast cancer; their relevance to the cancer risk is unclear and the association with the response to specific BRCA1/2-targeted agents is uncertain. To minimise the proportion of VUS in BRCA1/2, we performed the multifactorial likelihood analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to Global Cancer Incidence and Screening
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30415210
DOI: 10.1136/jmedgenet-2018-105565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reclassification of BRCA1 and BRCA2 variants of uncertain significance: a multifactorial analysis of multicentre prospective cohortPMID 30415210Read ↗

Comparative analysis of BRCA1 and BRCA2 variants of uncertain significance in patients with breast cancer: a multifactorial probability-based model versus ACMG standards and guidelines for interpreting sequence variants.Semantic proximity Read ↗

A review of a multifactorial probability-based model for classification of BRCA1 and BRCA2 variants of uncertain significance (VUS).Semantic proximity Read ↗

BRCA1/2 sequence variants of uncertain significance: a primer for providers to assist in discussions and in medical management.Semantic proximity Read ↗

Analysis of BRCA1/2 variants of unknown significance in patients with breast cancer from a prospective KOHBRA studySemantic proximity Read ↗

How does re-classification of variants of unknown significance (VUS) impact the management of patients at risk for hereditary breast cancer?Semantic proximity Read ↗

BRCA1/2 variants of unknown significance in hereditary breast and ovarian cancer (HBOC) syndrome: Looking for the hidden meaning.Semantic proximity Read ↗

Analysis of BRCA1/2 variants of unknown significance in the prospective Korean Hereditary Breast Cancer study.Semantic proximity Read ↗

Unclassified variants in BRCA genes: guidelines for interpretation.Semantic proximity Read ↗

Retrospective reinterpretation and reclassification of BRCA1/2 variants from Chinese population.Semantic proximity Read ↗

Classification and Clinical Management of Variants of Uncertain Significance in High Penetrance Cancer Predisposition Genes.Semantic proximity Read ↗

A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history.Semantic proximity Read ↗

Challenges in periodic revision of genetic testing results: Comparison of the main classification guidelines and report of a retrospective analysis involving BRCA1/BRCA2 variants of uncertain significance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.