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Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma

6 Nov 2018

Abstract excerpt

Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously demonstrated that Proviral Integration site for Moloney murine leukemia (PIM) kinases promote tumorigenesis in hepatoblastoma. Stem cell-like cancer cells (SCLCCs) are a subset of cells thought to be responsible for chemoresistance, metastasis, relapse, and...

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PMID: 30412911
DOI: 10.1016/j.tranon.2018.10.008

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