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Article

Inhibition of PIM Kinases Promotes Neuroblastoma Cell Differentiation to a Neuronal Phenotype.

Journal of pediatric surgery - 1 Jun 2023

Julson Janet R, Quinn Colin H, Bownes Laura V, Hutchins Sara C, Stewart Jerry E, Aye Jamie, Yoon Karina J, Beierle Elizabeth A

Abstract excerpt

BACKGROUND: Neuroblastoma arises from aberrancies in neural stem cell differentiation. PIM kinases contribute to cancer formation, but their precise role in neuroblastoma tumorigenesis is poorly understood. In the current study, we evaluated the effects of PIM kinase inhibition on neuroblastoma differentiation. METHODS: Versteeg database query assessed the correlation between PIM gene expression and the...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Source

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Identifiers

PMID: 36907773
DOI: 10.1016/j.jpedsurg.2023.02.018
PMCID: PMC10198809

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