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Article

YTHDC1 modulates the malignant phenotype of retinoblastoma via SQSTM1-mediated autophagy.

Scientific reports - 27 Jan 2026

Ding Jie, Sun Jie, Wang Jinghan, Ma Ruiqi, Xue Kang, Qian Jiang

Abstract excerpt

Retinoblastoma (RB) is the most common pediatric intraocular malignancy, yet the role of N6-methyladenosine (m6A) regulators in RB progression remains unclear. This study investigated the function and mechanism of the m6A reader YTHDC1 in RB invasion. The RNA-sequencing dataset GSE97508 from Gene Expression Omnibus was analyzed to identify differentially expressed m6A regulators between invasive and non-invasive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41593297
DOI: 10.1038/s41598-026-36833-3
PMCID: PMC12905150

Genes

YTHDC1
SQSTM1
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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