miR-15a/miR-16-1 expression inversely correlates with cyclin D1 levels in Men1 pituitary NETs

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pituitary and pancreatic islet tumours, and is due to mutations of the MEN1 gene, which encodes the tumour suppressor protein menin. Menin has multiple roles in genome stability, transcription, cell division and proliferation, but its mechanistic roles in tumourigenesis remain to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromatin Remodeling and Cancer
• Share to MicroRNA in disease regulation
• Share to Neuroendocrine Tumor Research Advances