Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin.

Future medicinal chemistry - 1 May 2021

Sun Kewei, Sun Zhonghao, Zhao Fenglan, Shan Guangzhi, Meng Qingguo

Abstract excerpt

Microtubules have been a concerning target of cancer chemotherapeutics for decades, and several tubulin-targeted agents, such as paclitaxel, vincristine and vinorelbine, have been approved. The colchicine binding site is one of the primary targets on microtubules and possesses advantages compared with other tubulin-targeted agents, such as inhibitors of tumor vessels and overcoming P-glycoprotein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Colchicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Screening Assays, Antitumor

Share to Microtubules

Share to Molecular Docking Simulation

Share to Molecular Targeted Therapy

Share to Tubulin

Share to Tubulin Modulators

Source

Identifiers

PMID: 33821673
DOI: 10.4155/fmc-2020-0376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin.PMID 33821673Read ↗

Docking Study of Ligands into the Colchicine Binding Site of TubulinSemantic proximity Read ↗

Mechanisms of Tubulin Binding Ligands to Target Cancer Cells: Updates on their Therapeutic Potential and Clinical TrialsSemantic proximity Read ↗

Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluationSemantic proximity Read ↗

Microtubules and Cell Division: Potential Pharmacological Targets in Cancer TherapySemantic proximity Read ↗

A review of research progress of antitumor drugs based on tubulin targetsSemantic proximity Read ↗

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine DerivativesSemantic proximity Read ↗

Discovery of Small Molecule Inhibitors that Interact with γ‐TubulinSemantic proximity Read ↗

Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer ActivitySemantic proximity Read ↗

Microtubulin Binding Sites as Target for Developing Anticancer AgentsSemantic proximity Read ↗

PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of TubulinSemantic proximity Read ↗

Design and Biological Evaluation of Novel Tubulin Inhibitors as Antimitotic Agents Using a Pharmacophore Binding Model with TubulinSemantic proximity Read ↗

Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing AgentsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.