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Article

Discovery of Small Molecule Inhibitors that Interact with γ‐Tubulin

23 Jan 2012

Abstract excerpt

Recent studies have shown an overexpression of γ-tubulin in human glioblastomas and glioblastoma cell lines. As the 2-year survival rate for glioblastoma is very poor, potential benefit exists for discovering novel chemotherapeutic agents that can inhibit γ-tubulin, which is known to form a ring complex that acts as a microtubule nucleation center. We present experimental evidence that colchicine and...

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PMID: 22268380
DOI: 10.1111/j.1747-0285.2012.01340.x

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