Article
Insights into imprinting from parent-of-origin phased methylomes and transcriptomes.
Nature genetics - 1 Nov 2018
Zink Florian, Magnusdottir Droplaug N, Magnusson Olafur T, Walker Nicolas J, Morris Tiffany J, Sigurdsson Asgeir, Halldorsson Gisli H, Gudjonsson Sigurjon A, Melsted Pall, Ingimundardottir Helga, Kristmundsdottir Snædis, Alexandersson Kristjan F, Helgadottir Anna, Gudmundsson Julius, Rafnar Thorunn, Jonsdottir Ingileif, Holm Hilma, Eyjolfsson Gudmundur Ingi, Sigurdardottir Olof, Olafsson Isleifur, Masson Gisli, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Halldorsson Bjarni V, Stacey Simon N, Stefansson Kari
Abstract excerpt
Imprinting is the preferential expression of one parental allele over the other. It is controlled primarily through differential methylation of cytosine at CpG dinucleotides. Here we combine 285 methylomes and 11,617 transcriptomes from peripheral blood samples with parent-of-origin phased haplotypes, to produce a new map of imprinted methylation and gene expression patterns across the human genome. We...
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