Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Re-thinking Alzheimer's disease therapeutic targets using gene-based tests

9 Oct 2018

Abstract excerpt

Background Alzheimer's disease (AD) is a devastating condition with no known effective drug treatments. Existing drugs only alleviate symptoms. Given repeated expensive drug failures, we assessed systematically whether approved and investigational AD drugs are targeting products of genes strongly associated with AD and whether these genes are targeted by existing drugs for other indications which could be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Bioinformatics and Genomic Networks
Share to Computational Drug Discovery Methods

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30314892
DOI: 10.1016/j.ebiom.2018.10.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Re-thinking Alzheimer's disease therapeutic targets using gene-based testsPMID 30314892Read ↗

Comprehensive adjudication identifies 111 high-confidence loci for Alzheimer's disease and related dementiasSemantic proximity Read ↗

The common genes involved in the pathogenesis of Alzheimer's disease and type 2 diabetes and their implication for drug repositioningSemantic proximity Read ↗

Biological and disease hallmarks of Alzheimer’s disease defined by Alzheimer’s disease genesSemantic proximity Read ↗

Untangling huge literature to disinter genetic underpinnings of Alzheimer's Disease: A systematic review and meta-analysis.Semantic proximity Read ↗

Ask the doctor. Alzheimer's runs in my family. Will it help to get gene testing for this disease?Semantic proximity Read ↗

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative DiseasesSemantic proximity Read ↗

Decoding the Genetic Comorbidity Network of Alzheimer's DiseaseSemantic proximity Read ↗

Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations'.Semantic proximity Read ↗

4 new genes identified as raising Alzheimer's disease risk. A multi-center research project unveils more targets to study for potential future treatment.Semantic proximity Read ↗

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.Semantic proximity Read ↗

Identification of potential drug targets for Alzheimer's disease from genetic insights: A Mendelian randomization study.Semantic proximity Read ↗

Cross-phenotype associations between Alzheimer’s Disease and its comorbidities may provide clues to progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.