Article
Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia.
Nature communications - 10 Oct 2018
McMaster Mary L, Berndt Sonja I, Zhang Jianqing, Slager Susan L, Li Shengchao Alfred, Vajdic Claire M, Smedby Karin E, Yan Huihuang, Birmann Brenda M, Brown Elizabeth E, Smith Alex, Kleinstern Geffen, Fansler Mervin M, Mayr Christine, Zhu Bin, Chung Charles C, Park Ju-Hyun, Burdette Laurie, Hicks Belynda D, Hutchinson Amy, Teras Lauren R, Adami Hans-Olov, Bracci Paige M, McKay James, Monnereau Alain, Link Brian K, Vermeulen Roel C H, Ansell Stephen M, Maria Ann, Diver W Ryan, Melbye Mads, Ojesina Akinyemi I, Kraft Peter, Boffetta Paolo, Clavel Jacqueline, Giovannucci Edward, Besson Caroline M, Canzian Federico, Travis Ruth C, Vineis Paolo, Weiderpass Elisabete, Montalvan Rebecca, Wang Zhaoming, Yeager Meredith, Becker Nikolaus, Benavente Yolanda, Brennan Paul, Foretova Lenka, Maynadie Marc, Nieters Alexandra, de Sanjose Silvia, Staines Anthony, Conde Lucia, Riby Jacques, Glimelius Bengt, Hjalgrim Henrik, Pradhan Nisha, Feldman Andrew L, Novak Anne J, Lawrence Charles, Bassig Bryan A, Lan Qing, Zheng Tongzhang, North Kari E, Tinker Lesley F, Cozen Wendy, Severson Richard K, Hofmann Jonathan N, Zhang Yawei, Jackson Rebecca D, Morton Lindsay M, Purdue Mark P, Chatterjee Nilanjan, Offit Kenneth, Cerhan James R, Chanock Stephen J, Rothman Nathaniel, Vijai Joseph, Goldin Lynn R, Skibola Christine F, Caporaso Neil E
Abstract excerpt
Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40-31.03, P = 1.36 × 10-54) and 14q32.13...
