MicroRNA-122a Regulates Zonulin by Targeting EGFR in Intestinal Epithelial Dysfunction

Abstract excerpt

BACKGROUND/AIMS: This study aimed to investigate the role of microRNA (miR)-122a in regulating zonulin during the modulation of intestinal barrier. METHODS: Zonulin proteins and their target gene expression were analyzed in miR-122a-overexpressing cell lines and in the target gene of epidermal growth factor receptor (EGFR). An mmu-miR-122a intestinal epithelial conditional transgenic (miR-122a-TG) mouse model was...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Barrier Structure and Function Studies
• Share to Helicobacter pylori-related gastroenterology studies
• Share to MicroRNA in disease regulation