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Article

How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma

1 Jan 2018

Abstract excerpt

Rap proteins regulate liver physiopathology. For example, Rap2B promotes hepatocarcinoma (HCC) growth, while Rap1 might play a dual role. The RapGEF, Epac1, activates Rap upon cAMP binding, regulating metabolism, survival, and liver regeneration. A liver specific Epac2 isoform lacking cAMP-binding domain also activates Rap1, promoting fibrosis in alcoholic liver disease. C3G (RapGEF1) is also present in the...

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PMID: 30302196
DOI: 10.2217/hep-2017-0026

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