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Mevalonate Metabolism in Cancer Stemness and Trained Immunity

20 Sept 2018

Abstract excerpt

Mevalonate metabolism provides cancer and immune cells with diverse products to ensure cell functionality. Similar metabolic reprogramming that raises mevalonate metabolism to higher levels appears to drive both, epithelial mesenchymal transition (EMT) of cancer cells, a reverse differentiation program that generates cancer cells with stem cell properties, and immune cell training for increased responsiveness to...

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PMID: 30298120
DOI: 10.3389/fonc.2018.00394

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