Article
The control of adaptive immune responses by the innate immune system.
Advances in immunology - 1 Jan 2011
Schenten Dominik, Medzhitov Ruslan
Abstract excerpt
The mammalian immune system comprises an adaptive and an innate component. The innate immune system employs a limited number of germ-line-encoded pattern-recognition receptors (PRRs) that recognize invariant pathogen-associated molecular patterns (PAMPs). In contrast, the adaptive immune system depends on the generation of a diverse repertoire of antigen receptors on T and B lymphocytes and subsequent activation...
Topics
- Adaptive Immunity
- Animals
- Cell Communication
- Humans
- Immunity, Innate
- Infections
- Mutation
- Receptors, Antigen
- Receptors, Pattern Recognition
- Signal Transduction