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The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

24 Sept 2018

Abstract excerpt

SARS-coronavirus (CoV) is a zoonotic agent derived from rhinolophid bats, in which a plethora of SARS-related, conspecific viral lineages exist. Whereas the variability of virulence among reservoir-borne viruses is unknown, it is generally assumed that the emergence of epidemic viruses from animal reservoirs requires human adaptation. To understand the influence of a viral factor in relation to interspecies...

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PMID: 30248143
DOI: 10.1371/journal.ppat.1007296

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