Article

The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model

2019-08-29

Abstract excerpt

<h4> Abstract </h4> Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause zoonotic infections and serious disease, primarily in the Arabian Peninsula, due to repeated spill-over from dromedary camels and subsequent nosocomial transmission. Approved MERS vaccines for use in animals or humans are not currently available. MERS-CoV replication requires the virus-encoded papain-like protease (PL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 731ad663-cfb2-507d-a5dd-ec74e04f67ef
DOI: 10.1101/751578

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse modelDOI 10.1101/751578Read

Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.Semantic proximity Read

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivoSemantic proximity Read

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variantsSemantic proximity Read

Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active siteSemantic proximity Read

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severitySemantic proximity Read

Role of E3 ubiquitin ligases and deubiquitinating enzymes in SARS-CoV-2 infectionSemantic proximity Read

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.Semantic proximity Read

The Role of Deubiquitinases in Virus Replication and Host Innate Immune ResponseSemantic proximity Read

E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and ExploitationSemantic proximity Read

Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.Semantic proximity Read

Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I SignalingSemantic proximity Read

The Role of the Host Ubiquitin System in Promoting Replication of Emergent VirusesSemantic proximity Read