Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission.

Journal of virology - 1 Dec 2016

Anggakusuma, Brown Richard J P, Banda Dominic H, Todt Daniel, Vieyres Gabrielle, Steinmann Eike, Pietschmann Thomas

Abstract excerpt

Multiple novel members of the genus Hepacivirus have recently been discovered in diverse mammalian species. However, to date, their replication mechanisms and zoonotic potential have not been explored in detail. The NS3/4A serine protease of hepatitis C virus (HCV) is critical for cleavage of the viral polyprotein. It also cleaves the cellular innate immune adaptor MAVS, thus decreasing interferon (IFN)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C

Share to Host Specificity

Share to Immunity, Innate

Share to Serine Proteases

Share to Viral Nonstructural Proteins

Share to Zoonoses

Source

Open in PubMed Open full text

Identifiers

PMID: 27654291
DOI: 10.1128/JVI.01634-16
PMCID: PMC5110154

Genes

MAVS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission.PMID 27654291Read ↗

Convergent Evolution of Escape from Hepaciviral Antagonism in PrimatesSemantic proximity Read ↗

Picornavirus 3C Proteins Intervene in Host Cell Processes through Proteolysis and Interactions with RNASemantic proximity Read ↗

The Strange, Expanding World of Animal Hepaciviruses.Semantic proximity Read ↗

Enterovirus D68 3C protease antagonizes type I interferon signaling by cleaving signal transducer and activator of transcription 1Semantic proximity Read ↗

Running With Scissors: Evolutionary Conflicts Between Viral Proteases and the Host Immune SystemSemantic proximity Read ↗

The coronavirus 3CL protease: Unveiling its complex host interactions and central role in viral pathogenesisSemantic proximity Read ↗

Evolutionary origins of hepatitis A virus in small mammalsSemantic proximity Read ↗

NSs: the multifaceted bunyavirus virulence factorSemantic proximity Read ↗

Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell deathSemantic proximity Read ↗

Animal morbilliviruses and their cross-species transmission potentialSemantic proximity Read ↗

SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hostsSemantic proximity Read ↗

Viral hepatitis and primates: historical and molecular analysis of human and nonhuman primate hepatitis A, B, and the GB‐related virusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.