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Article

HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1

19 Sept 2018

Abstract excerpt

HPV16 is the predominant type of HPV causing invasive cervical cancer. However, the underlying molecular mechanism of the unparalleled carcinogenic power of HPV16 compared to other types of high-risk (HR)-HPV including HPV18 remains elusive. The PDZ binding motif (PBM) of high-risk HPV E6 plays an important role in neoplasia and progression of cervical cancer. HPV16 E6 rather than HPV18 E6, interacted with NHERF1...

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PMID: 30230542
DOI: 10.1002/ijc.31876

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