Unique, Gender-Dependent Serum microRNA Profile in PLS3 Gene-Related Osteoporosis.

Abstract excerpt

Plastin 3 (PLS3), encoded by PLS3, is a newly recognized regulator of bone metabolism, and mutations in the encoding gene result in severe childhood-onset osteoporosis. Because it is an X chromosomal gene, PLS3 mutation-positive males are typically more severely affected whereas females portray normal to increased skeletal fragility. Despite the severe skeletal pathology, conventional metabolic bone markers tend...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone and Bones
• Share to Finland