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Article

Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota.

Nature microbiology - 1 Oct 2018

Martin Patricia K, Marchiando Amanda, Xu Ruliang, Rudensky Eugene, Yeung Frank, Schuster Samantha L, Kernbauer Elisabeth, Cadwell Ken

Abstract excerpt

As a conserved pathway that lies at the intersection between host defence and cellular homeostasis, autophagy serves as a rheostat for immune reactions. In particular, autophagy suppresses excess type I interferon (IFN-I) production in response to viral nucleic acids. It is unknown how this function of autophagy relates to the intestinal barrier where host-microbe interactions are pervasive and perpetual. Here,...

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Identifiers

PMID: 30202015
DOI: 10.1038/s41564-018-0229-0
PMCID: PMC6179362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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