Article
MicroRNA-98 regulates hepatic cholesterol metabolism via targeting sterol regulatory element-binding protein 2.
Biochemical and biophysical research communications - 2 Oct 2018
Geng Chong, Dong Tianyi, Jin Weilong, Yu Bo, Yin Fuhui, Peng Fengqiang, Chen Guanmin, Ji Chuncai, Ding Feng
Abstract excerpt
Hypercholesterolemia is an important risk factor for coronary heart disease. Although a lot of research has been conducted, the regulation of cholesterol metabolism is still largely unknown. Some miRNAs have been found to play critical role in the cholesterol metabolism. MiR-98 is a miRNA whose function has been reported mainly in tumorigenesis. In this study, we elucidate a novel role of miR-98 in cholesterol...
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