Article
Decoding the Genomics of Abdominal Aortic Aneurysm.
Cell - 6 Sept 2018
Li Jingjing, Pan Cuiping, Zhang Sai, Spin Joshua M, Deng Alicia, Leung Lawrence L K, Dalman Ronald L, Tsao Philip S, Snyder Michael
Abstract excerpt
A key aspect of genomic medicine is to make individualized clinical decisions from personal genomes. We developed a machine-learning framework to integrate personal genomes and electronic health record (EHR) data and used this framework to study abdominal aortic aneurysm (AAA), a prevalent irreversible cardiovascular disease with unclear etiology. Performing whole-genome sequencing on AAA patients and controls,...
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