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Article

Cytotoxicity analysis of staphylococcal bi-component β-pore forming toxins using the CHO cells expressing human lymphocyte receptor CCR5.

Bioscience, biotechnology, and biochemistry - 1 Dec 2018

Peng Zhao, Shibata Nao, Tada Hideaki, Kaneko Jun

Abstract excerpt

CCR5-mediated cytotoxicity of staphylococcal bi-component toxins was investigated using human CCR5-expressing CHO cells. Cytotoxicity of rim domain loop-exchange mutants between LukE and Hlg2 indicated that loop-4 of LukE is essential for cytotoxicity in combination with LukD. Interestingly, Hlg2 showed LukF-dependent CCR5-mediated cytotoxicity, suggesting that the F-components of toxins also play a role in the...

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Share to Bacterial Toxins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CCR5

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Source

Identifiers

PMID: 30185128
DOI: 10.1080/09168451.2018.1515614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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