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Article

The influences of CYP2C91/3 genotype on the pharmacokinetics of zolpidem.

Archives of pharmacal research - 1 Sept 2018

Byeon Ji-Yeong, Kim Young-Hoon, Kim Se-Hyung, Lee Choong-Min, Jung Eui-Hyun, Chae Won-Ki, Jang Choon-Gon, Lee Seok-Yong, Lee Yun Jeong

Abstract excerpt

Zolpidem is predominantly metabolized by CYP3A4, and to a lesser extent by CYP2C9, CYP1A2, CYP2D6 and CYP2C19. The aim of this study was to identify the effects of CYP2C9*3 allele on the pharmacokinetics of zolpidem. Healthy male subjects were divided into two genotype groups, CYP2C9*1/*1 and CYP2C9*1/*3. They received a single oral dose of 5 mg zolpidem, and the plasma concentrations of zolpidem were determined...

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PMID: 30178440
DOI: 10.1007/s12272-018-1070-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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