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Article

A model for positive feedback control of the transformation of fibroblasts to myofibroblasts.

Progress in biophysics and molecular biology - 1 Jul 2019

Elson Elliot L, Qian Hong, Fee Judy A, Wakatsuki Tetsuro

Abstract excerpt

The phenotypic conversion of normal fibroblasts to myofibroblasts is central to normal wound healing and to pathological fibrosis that can occur in the heart and many other tissues. The transformation occurs in two stages. The first stage is driven mainly by mechanical changes such as increased stiffness of the heart due to hypertension and cellular contractility. The second stage requires both increasing...

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Identifiers

PMID: 30174171
DOI: 10.1016/j.pbiomolbio.2018.08.004
PMCID: PMC11033709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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