Article
KCNJ11 variants and their effect on the association between serum potassium and diabetes risk in the Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) cohorts.
PloS one - 1 Jan 2018
Chatterjee Ranee, Davenport Clemontina A, Raffield Laura M, Maruthur Nisa, Lange Leslie, Selvin Elizabeth, Butler Kenneth, Yeh Hsin-Chieh, Wilson James G, Correa Adolfo, Edelman David, Hauser Elizabeth
Abstract excerpt
BACKGROUND: In the Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) cohorts, serum potassium (K) is an independent predictor of diabetes risk, particularly among African-American participants. Experimental studies show that serum K levels affects insulin secretion. The KCNJ11 gene encodes for a K channel that regulates insulin secretion and whose function is affected by serum K...
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