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Article

A mating-type mutagenesis screen identifies a zinc-finger protein required for specific DNA excision events in Paramecium.

Nucleic acids research - 12 Oct 2018

Bhullar Simran, Denby Wilkes Cyril, Arnaiz Olivier, Nowacki Mariusz, Sperling Linda, Meyer Eric

Abstract excerpt

In the ciliate Paramecium tetraurelia, functional genes are reconstituted during development of the somatic macronucleus through the precise excision of ∼45 000 single-copy Internal Eliminated Sequences (IESs), thought to be the degenerate remnants of ancient transposon insertions. Like introns, IESs are marked only by a weak consensus at their ends. How such a diverse set of sequences is faithfully recognized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30165457
DOI: 10.1093/nar/gky772
PMCID: PMC6182129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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