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Article

The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death.

International journal of molecular sciences - 21 Nov 2016

Zhong Rui, Xin Rui, Chen Zongyan, Liang Nan, Liu Yang, Ma Shumei, Liu Xiaodong

Abstract excerpt

Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs. dCK is activated in response to ionizing radiation (IR)-induced DNA damage and it is phosphorylated on Serine 74 by the Ataxia-Telangiectasia Mutated (ATM) kinase in order to activate the cell cycle G2/M checkpoint. However, whether dCK plays a role in radiation-induced cell death is...

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Identifiers

PMID: 27879648
DOI: 10.3390/ijms17111939
PMCID: PMC5133934

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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