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Article

Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.

Biochemistry - 25 Sept 2018

Shen Yi-Chung, Sasaki Toshikazu, Matsuyama Take, Yamashita Takahiro, Shichida Yoshinori, Okitsu Takashi, Yamano Yumiko, Wada Akimori, Ishizuka Toru, Yawo Hiromu, Imamoto Yasushi

Abstract excerpt

As optogenetic studies become more popular, the demand for red-shifted channelrhodopsin is increasing, because blue-green light is highly scattered or absorbed by animal tissues. In this study, we developed a red-shifted channelrhodopsin by elongating the conjugated double-bond system of the native chromophore, all -trans-retinal (ATR1). Analogues of ATR1 and ATR2 (3,4-didehydro-retinal) in which an extra C═C...

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Identifiers

PMID: 30153419
DOI: 10.1021/acs.biochem.8b00583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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