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Article

Somatostatin receptor 2 signaling promotes growth and tumor survival in small‐cell lung cancer

29 Aug 2018

Abstract excerpt

Somatostatin receptor 2 (SSTR2) is overexpressed in a majority of neuroendocrine neoplasms, including small-cell lung carcinomas (SCLCs). SSTR2 was previously considered an inhibitory receptor on cell growth, but its agonists had poor clinical responses in multiple clinical trials. The role of this receptor as a potential therapeutic target in lung cancer merits further investigation. We evaluated the expression...

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PMID: 30152518
DOI: 10.1002/ijc.31771

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